ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex.

ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex.

Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear. Moreover, for differentiation to progress, FGF signalling must decline. Why these signalling dynamics are required has n...

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Bibliographic Details
Main Authors: Claudia I Semprich, Lindsay Davidson, Adriana Amorim Torres, Harshil Patel, James Briscoe, Vicki Metzis, Kate G Storey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000221

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https://doi.org/10.1371/journal.pbio.3000221

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