The extrahepatic role of TFR2 in iron homeostasis

The extrahepatic role of TFR2 in iron homeostasis

Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer transferrin receptor 1 (TFR1), is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1. TFR2 gene is mutated in type 3 hemochromatosis, a disorder ch...

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Bibliographic Details
Main Authors: Laura eSilvestri, Antonella eNai, Alessia ePagani, Clara eCamaschella
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Pharmacology
Subjects:
Erythroid Cells
Iron
hepcidin
TFR2
TMPRSS6
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00093/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00093/full

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