L-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial)

L-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial)

Abstract Background Migraine is a common and distressing neurological condition characterised by recurrent throbbing headaches, nausea and heightened sensitivity to light and sound. Accumulating evidence suggests that cerebral arteries dilate during migraine, causing distal microvessels to constrict...

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Bibliographic Details
Main Authors: Devahuti R. Chaliha, Mauro Vaccarezza, Emily Corti, Ryusuke Takechi, Satvinder S. Dhaliwal, Peter Drummond, Eric Visser, Fred K. Chen, Jason Charng, Virginie Lam, John C.L. Mamo
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Neurology
Subjects:
Aged garlic extract
L-arginine
Chronic frequent episodic migraine
Photosensitivity
Randomised controlled trial
Retinal imaging
Online Access:https://doi.org/10.1186/s12883-023-03149-y

Internet

https://doi.org/10.1186/s12883-023-03149-y

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