Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers.

Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers.

Under normoxia, non-malignant cells rely on oxidative phosphorylation for their ATP production, whereas cancer cells rely on Glycolysis; a phenomenon known as the Warburg effect. We aimed to elucidate the mechanisms contributing to the Warburg effect in human breast cancer.Lactate Dehydrogenase (LDH...

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Bibliographic Details
Main Authors: Nicola J Brown, Sue E Higham, Branko Perunovic, Mohammad Arafa, Sabapathy Balasubramanian, Ishtiaq Rehman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3578788?pdf=render

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http://europepmc.org/articles/PMC3578788?pdf=render

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