Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors

Abstract Ferroptosis induced by detrimental accumulation of lipid peroxides has been recently linked to a variety of pathological conditions ranging from acute tissue injuries to chronic degenerative diseases and suppression of ferroptosis by small chemical inhibitors is beneficial to the prevention...

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Bibliographic Details
Main Authors: Yipu Fan, Yihan Zhang, Kunyu Shi, Shan Cheng, Duanqing Pei, Xiaodong Shu
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05447-8