GSK-3β Inhibitor Alsterpaullone Attenuates MPP+-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells

GSK-3β Inhibitor Alsterpaullone Attenuates MPP+-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells

Mitochondrial dysfunction plays significant roles in the pathogenesis of Parkinson’s Disease (PD). The inactivation of c-Myc, a down-stream gene of Wnt/β-catenin signaling, may contribute to the mitochondria dysfunction. Inhibition of glycogen synthase kinase 3β (GSK-3β) with Alsterpaullone (Als) ca...

Full description

Bibliographic Details
Main Authors: Jiancai Wang, Yuqian Li, Li Gao, Fengqi Yan, Guodong Gao, Lihong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson’s disease
mitochondria
wnt signaling
c-Myc
alsterpaullone
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00283/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00283/full

Similar Items