Conditional Knockout of N-WASP Enhanced the Formation of Keratinizing Squamous Cell Carcinoma Induced by KRas<sup>G12D</sup>

Conditional Knockout of N-WASP Enhanced the Formation of Keratinizing Squamous Cell Carcinoma Induced by KRas<sup>G12D</sup>

Squamous cell carcinoma (SCC) is one of the most common forms of skin cancer in humans, and Neural Wiskott-Aldrich Syndrome Protein (N-WASP) plays a crucial role in epidermal homeostasis. To elucidate the role of N-WASP in skin cancer, we generated mice which expressed constitutively active KRas (KR...

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Bibliographic Details
Main Authors: Pazhanichamy Kalailingam, Apoorva Verma, Ying Hui Lee, Thirumaran Thanabalu
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cancers
Subjects:
N-WASP
keratin pearl
skin cancer
Online Access:https://www.mdpi.com/2072-6694/15/18/4455

Internet

https://www.mdpi.com/2072-6694/15/18/4455

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