T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation

T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation

Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucleus. The role of the PTPs Src-homology 2 (SH2) domain-containi...

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Bibliographic Details
Main Authors: Clemens Cammann, Nicole Israel, Sarah Frentzel, Andreas Jeron, Eylin Topfstedt, Thomas Schüler, Luca Simeoni, Martin Zenker, Hans Joerg Fehling, Burkhart Schraven, Dunja Bruder, Ulrike Seifert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
T cell receptor signaling
Src homology region 2 domain-containing protein-tyrosine phosphatase 2 (SHP2)
SHP2 gain-of-function mutation
T lymphocyte
effector memory T cells (TEMs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.958616/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.958616/full

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