MicroRNA-related cofilin abnormality in Alzheimer's disease.
Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-12-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3002958?pdf=render |
| _version_ | 1811192264331886592 |
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| author | Jiaqi Yao Tom Hennessey Alex Flynt Eric Lai M Flint Beal Michael T Lin |
| author_facet | Jiaqi Yao Tom Hennessey Alex Flynt Eric Lai M Flint Beal Michael T Lin |
| author_sort | Jiaqi Yao |
| collection | DOAJ |
| description | Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD. These results suggest that microRNAs may play an important role in cytoskeletal pathology in AD. |
| first_indexed | 2024-04-11T23:48:26Z |
| format | Article |
| id | doaj.art-31a0e9274eda4838bb228557c7a3fc9d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T23:48:26Z |
| publishDate | 2010-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-31a0e9274eda4838bb228557c7a3fc9d2022-12-22T03:56:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-12-01512e1554610.1371/journal.pone.0015546MicroRNA-related cofilin abnormality in Alzheimer's disease.Jiaqi YaoTom HennesseyAlex FlyntEric LaiM Flint BealMichael T LinRod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD. These results suggest that microRNAs may play an important role in cytoskeletal pathology in AD.http://europepmc.org/articles/PMC3002958?pdf=render |
| spellingShingle | Jiaqi Yao Tom Hennessey Alex Flynt Eric Lai M Flint Beal Michael T Lin MicroRNA-related cofilin abnormality in Alzheimer's disease. PLoS ONE |
| title | MicroRNA-related cofilin abnormality in Alzheimer's disease. |
| title_full | MicroRNA-related cofilin abnormality in Alzheimer's disease. |
| title_fullStr | MicroRNA-related cofilin abnormality in Alzheimer's disease. |
| title_full_unstemmed | MicroRNA-related cofilin abnormality in Alzheimer's disease. |
| title_short | MicroRNA-related cofilin abnormality in Alzheimer's disease. |
| title_sort | microrna related cofilin abnormality in alzheimer s disease |
| url | http://europepmc.org/articles/PMC3002958?pdf=render |
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