Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

Lineage tracing approaches have provided new insights into the cellular mechanisms that support tissue homeostasis in mice. However, the relevance of these discoveries to human epithelial homeostasis and its alterations in disease is unknown. By developing a novel quantitative approach for the analy...

Full description

Bibliographic Details
Main Authors: Vitor H Teixeira, Parthiban Nadarajan, Trevor A Graham, Christodoulos P Pipinikas, James M Brown, Mary Falzon, Emma Nye, Richard Poulsom, David Lawrence, Nicholas A Wright, Stuart McDonald, Adam Giangreco, Benjamin D Simons, Sam M Janes
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-10-01
Series:eLife
Subjects:
Human lineage tracing
mtDNA mutation
lung basal progenitor stem cell
stochastic homeostasis
airway
Online Access:https://elifesciences.org/articles/00966

Internet

https://elifesciences.org/articles/00966

Similar Items