Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum

Malaria, an infectious disease caused by protozoan parasites from the genus Plasmodium, represents a serious global health threat. The continued emergence of drug resistant strains has severely decreased current antimalarial drug efficacy and led to a perpetual race for drug discovery. Most protozoa...

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Bibliographic Details
Main Authors: Christopher D. Grube, Cameron P. Gill, Hervé Roy
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:SLAS Discovery
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555221000216