Translation of Hepatitis A Virus IRES Is Upregulated by a Hepatic Cell-Specific Factor

Translation of Hepatitis A Virus IRES Is Upregulated by a Hepatic Cell-Specific Factor

Many viruses strongly prefer to infect certain cell types, a phenomenon known as “tropism.” Understanding tropism’s molecular basis is important for the design of vaccines and antiviral therapy. A common mechanism involves viral protein interactions with cell-specific surface receptors, but intracel...

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Bibliographic Details
Main Authors: Akitoshi Sadahiro, Akira Fukao, Mio Kosaka, Yoshinori Funakami, Naoki Takizawa, Osamu Takeuchi, Kent E. Duncan, Toshinobu Fujiwara
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Genetics
Subjects:
Hepatitis A Virus (HAV)
internal ribosome entry site (IRES)
translation regulation
tropism
translation initiation
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00307/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00307/full

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