Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological synapse.

Bibliographic Details
Main Authors: Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Štefan Bálint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28596-y