Heparan-6-<i>O</i>-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts

Heparan-6-<i>O</i>-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts

Local invasiveness of head and neck squamous cell carcinoma (HNSCC) is a complex phenomenon supported by interaction of the cancer cells with the tumor microenvironment (TME). We and others have shown that cancer-associated fibroblasts (CAFs) are a component of the TME that can promote local invasio...

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Bibliographic Details
Main Authors: Pritha Mukherjee, Xin Zhou, Julius Benicky, Aswini Panigrahi, Reem Aljuhani, Jian Liu, Laurie Ailles, Vitor H. Pomin, Zhangjie Wang, Radoslav Goldman
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
head and neck squamous cell carcinoma
cancer-associated fibroblast
heparan-6-<i>O</i>-endosulfatase
cancer invasion
Sulf-2 CRISPRCas9 knockout
Sulf-2 inhibitor
Online Access:https://www.mdpi.com/2072-6694/15/21/5168

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https://www.mdpi.com/2072-6694/15/21/5168

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