Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression

Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression

Screening of a protein kinase inhibitor library identified SB431542, targeting activin receptor-like kinase 5 (ALK5), as a compound interfering with SARS-CoV-2 replication. Since ALK5 is implicated in transforming growth factor β (TGF-β) signaling and regulation of the cellular endoprotease furin, w...

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Bibliographic Details
Main Authors: Maja C. Mezger, Carina Conzelmann, Tatjana Weil, Pascal von Maltitz, Dan P. J. Albers, Jan Münch, Thomas Stamminger, Eva-Maria Schilling
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
protein kinase inhibitor
ALK5
TFG-β
furin
Online Access:https://www.mdpi.com/1999-4915/14/6/1308

Internet

https://www.mdpi.com/1999-4915/14/6/1308

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