Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway

Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway

Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects against endothelial dysfunction, mitochondrial dysfunction, and DCM; however, its effects on ferroptosis and mitophagy remain u...

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Bibliographic Details
Main Authors: Zhangwei Chen, Su Li, Muyin Liu, Ming Yin, Jinxiang Chen, Youran Li, Qiyu Li, You Zhou, Yan Xia, Ao Chen, Danbo Lu, Chenguang Li, Yuqiong Chen, Juying Qian, Junbo Ge
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Pharmacological Research
Subjects:
Mitochondria-associated ferroptosis
Cardiac microvascular dysfunction
Diabetic cardiomyopathy
Mitophagy
AMPK signaling pathway
Nicorandil
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182400001X

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http://www.sciencedirect.com/science/article/pii/S104366182400001X

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