Increased METTL3 expression and m6A RNA methylation may contribute to the development of dry eye in primary Sjögren’s syndrome

Increased METTL3 expression and m6A RNA methylation may contribute to the development of dry eye in primary Sjögren’s syndrome

Abstract Background Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disorder defined by xerostomia and keratoconjunctivitis sicca, and its etiology remains unknown. N6-methyladenosine (m6A) is the predominant posttranscriptional modification in eukaryotic mRNAs and is dynamically regulated...

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Bibliographic Details
Main Authors: Jun Ma, Xiaotang Wang, Xue Yang, Xi Wang, Tongshan Tan, Hongping Fang, Yu Zhong, Qi Zhang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Ophthalmology
Subjects:
Primary Sjögren’s syndrome
Dry eye
N6-methyladenosine
METTL3
Online Access:https://doi.org/10.1186/s12886-023-02988-0

Internet

https://doi.org/10.1186/s12886-023-02988-0

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