Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion <i>in Vitro</i> and in Liver-Humanized Mice

Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion <i>in Vitro</i> and in Liver-Humanized Mice

Background: Alcohol abuse is common in people living with HIV-1 and dramatically<br />enhances the severity of HIV-induced liver damage by inducing oxidative stress and lysosomal<br />dysfunction in the liver cells. We hypothesize that the increased release of extracellular vesicles<b...

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Bibliographic Details
Main Authors: Raghubendra Singh Dagur, Moses New-Aaron, Murali Ganesan, Weimin Wang, Svetlana Romanova, Srivatsan Kidambi, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biology
Subjects:
small EVs
humanized mice
ethanol metabolism
liver disease
next-generation RNA sequencing
Online Access:https://www.mdpi.com/2079-7737/10/1/29

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https://www.mdpi.com/2079-7737/10/1/29

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