Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma.

Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma.

Multiple Myeloma (MM) is an incurable plasma cell cancer that is caused by several chromosomal translocations and gene deletions. Although deregulation of several signaling pathways including the Nuclear Factor-Kappa B (NF-κB) pathway has been reported in MM, the molecular requirement and the crosst...

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Bibliographic Details
Main Authors: Veena Potluri, Sunil K Noothi, Subrahmanya D Vallabhapurapu, Sang-Oh Yoon, James J Driscoll, Charles H Lawrie, Sivakumar Vallabhapurapu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3707888?pdf=render

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http://europepmc.org/articles/PMC3707888?pdf=render

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