The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

Summary: Conversion of promoter-proximally paused RNA polymerase II (RNAPII) into elongating polymerase by the positive transcription elongation factor b (P-TEFb) is a central regulatory step of mRNA synthesis. The activity of P-TEFb is controlled mainly by the 7SK small nuclear ribonucleoprotein (s...

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Bibliographic Details
Main Authors: Cécilia Studniarek, Michael Tellier, Pascal G.P. Martin, Shona Murphy, Tamás Kiss, Sylvain Egloff
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
7SK snRNP
P-TEFb
RNA polymerase II
promoter-proximal pausing
stress response
transcriptional reprogramming
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002795

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http://www.sciencedirect.com/science/article/pii/S2211124721002795

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