Frequency Evaluation of the <i>Interleukin-6</i> −174G>C Polymorphism and <i>Homeostatic Iron Regulator (HFE)</i> Mutations as Disease Modifiers in Patients Affected by Systemic Lupus Erythematosus and Rheumatoid Arthritis

Frequency Evaluation of the <i>Interleukin-6</i> −174G>C Polymorphism and <i>Homeostatic Iron Regulator (HFE)</i> Mutations as Disease Modifiers in Patients Affected by Systemic Lupus Erythematosus and Rheumatoid Arthritis

Autoimmune diseases are generally characterized by a multifactorial etiology and are often associated with a genetic predisposition. Both iron metabolism and the inflammatory cytokine system have been shown to play a pivotal role in the dysregulation of the immune response in many different autoimmu...

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Bibliographic Details
Main Authors: Mattia Carini, Micaela Fredi, Ilaria Cavazzana, Roberto Bresciani, Fabiana Ferrari, Eugenio Monti, Franco Franceschini, Giorgio Biasiotto
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
<i>HFE</i>
<i>IL-6</i>
iron metabolism
inflammation
systemic lupus erythematosus
rheumatoid arthritis
Online Access:https://www.mdpi.com/1422-0067/24/22/16300

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https://www.mdpi.com/1422-0067/24/22/16300

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