Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzymes is associated with cardiovascular disease,...

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Bibliographic Details
Main Authors: Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Redox Biology
Subjects:
NADPH Oxidase
Traumatic brain injury
Inhibitor
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000125

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http://www.sciencedirect.com/science/article/pii/S2213231723000125

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