CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis

CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis

Abstract Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joi...

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Bibliographic Details
Main Authors: Chengyu Yin, Boyu Liu, Zishan Dong, Sai Shi, Chenxing Peng, Yushuang Pan, Xiaochen Bi, Huimin Nie, Yunwen Zhang, Yan Tai, Qimiao Hu, Xuan Wang, Xiaomei Shao, Hailong An, Jianqiao Fang, Chuan Wang, Boyi Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47640-7

Internet

https://doi.org/10.1038/s41467-024-47640-7

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