IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice

IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice

IRF-7 mediates robust production of type I IFN via MyD88 of the TLR9 pathway in plasmacytoid dendritic cells (pDCs). Previous in vitro studies using bone marrow-derived dendritic cells lacking either Irf7 or Irf3 have demonstrated that only IRF-3 is required for IFN-β production in the TLR4 pathway....

Full description

Bibliographic Details
Main Authors: Wei-Xiang Sin, Joe Poh-Sheng Yeong, Thomas Jun Feng Lim, I-Hsin Su, John E. Connolly, Keh-Chuang Chin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
IRF-7
TLR4
IFN-β
IL-1β
macrophage
dendritic cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00640/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00640/full

Similar Items