An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.

An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.

Glioblastomas (GBM) may contain a variable proportion of active cancer stem cells (CSCs) capable of self-renewal, of aggregating into CD133(+) neurospheres, and to develop intracranial tumors that phenocopy the original ones. We hypothesized that nucleostemin may contribute to cancer stem cell biolo...

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Bibliographic Details
Main Authors: Jon Gil-Ranedo, Marina Mendiburu-Eliçabe, Mercedes García-Villanueva, Diego Medina, Marta del Álamo, Marta Izquierdo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3236221?pdf=render

Internet

http://europepmc.org/articles/PMC3236221?pdf=render

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