Impaired Development of Left Anterior Heart Field by Ectopic Retinoic Acid Causes Transposition of the Great Arteries

Impaired Development of Left Anterior Heart Field by Ectopic Retinoic Acid Causes Transposition of the Great Arteries

Background Transposition of the great arteries is one of the most commonly diagnosed conotruncal heart defects at birth, but its etiology is largely unknown. The anterior heart field (AHF) that resides in the anterior pharyngeal arches contributes to conotruncal development, during which heart proge...

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Bibliographic Details
Main Authors: Mayu Narematsu, Tatsuya Kamimura, Toshiyuki Yamagishi, Mitsuru Fukui, Yuji Nakajima
Format: Article
Language:English
Published: Wiley 2015-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
congenital
heart defects
Isl1
morphogenesis
transposition of great vessel
Online Access:https://doi.org/10.1161/JAHA.115.001889

Internet

https://doi.org/10.1161/JAHA.115.001889

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