Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples

Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples

The enzyme cytochrome P450 2D6 (CYP2D6) metabolises approximately 25% of commonly prescribed drugs, including analgesics, anti-hypertensives, and anti-depressants, among many others. Genetic variation in drug metabolising genes can alter how an individual responds to prescribed drugs, including pred...

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Bibliographic Details
Main Authors: Leonie M. Hitchman, Allamanda Faatoese, Tony R. Merriman, Allison L. Miller, Yusmiati Liau, Oscar E. E. Graham, Ping Siu Kee, John F. Pearson, Tony Fakahau, Vicky A. Cameron, Martin A. Kennedy, Simran D. S. Maggo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Genetics
Subjects:
CYP2D6
pharmacogenetics
Polynesian
Māori
Pasifika
drug response
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1016416/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.1016416/full

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