Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes

Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes

Colon tumors with deficient DNA mismatch repair (dMMR) are generally infiltrated by T cells more densely than tumors with proficient mismatch repair (pMMR). However, high numbers of tumor-infiltrating lymphocytes (TILs) are found in select pMMR tumors, and low numbers of TILs are seen in select dMMR...

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Bibliographic Details
Main Authors: Jin K. Kim, Chin-Tung Chen, Ajaratu Keshinro, Asama Khan, Canan Firat, Chad Vanderbilt, Neil Segal, Zsofia Stadler, Jinru Shia, Vinod P. Balachandran, Martin R. Weiser
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Colon cancer
tumor-infiltrating-lymphocytes
T-cell repertoire
tumor mutational burden
mismatch repair deficiency
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2054757

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2054757

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