Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model

Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model

Abstract Background Epileptic seizure is a process of energy accumulation, bursting, and depletion accompanied by the production, spread, and termination of epileptic discharges. The energy required for a seizure is mainly provided through mitochondrial production of ATP. Mitochondrial diseases ofte...

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Bibliographic Details
Main Authors: Guohui Jiang, Shenglin Wang, Mingyue Chen, Xiaomi Ding, Weiwei He, Li Wang, Shunxian Wang, Juming Yu, Xiaoming Wang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Acta Epileptologica
Subjects:
Epilepsy
Mitochondria
Energy metabolism
Insulin receptor
IGF-1 receptor
Akt signaling
Online Access:https://doi.org/10.1186/s42494-021-00054-0

Internet

https://doi.org/10.1186/s42494-021-00054-0

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