3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosineResearch in context

3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosineResearch in context

Summary: Background: Miltefosine treatment failure in visceral leishmaniasis in Brazil has been associated with deletion of the miltefosine susceptibility locus (MSL) in Leishmania infantum. The MSL comprises four genes, 3′-nucleotidase/nucleases (NUC1 and NUC2); helicase-like protein (HLP); and 3,...

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Main Authors: Juliana B.T. Carnielli, Anuja Dave, Audrey Romano, Sarah Forrester, Pedro R. de Faria, Renata Monti-Rocha, Carlos H.N. Costa, Reynaldo Dietze, Ian A. Graham, Jeremy C. Mottram
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EBioMedicine
Subjects:
Miltefosine resistance
Visceral leishmaniasis
CRISPR-Cas9
3'nucleotidase/nuclease
Prognostic marker
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005606

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http://www.sciencedirect.com/science/article/pii/S2352396422005606

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