New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies

New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies

Diabetes mellitus (DM) is a metabolic disorder majorly arising from the pathophysiology of the pancreas manifested as a decline in the insulin production or the tissue’s resistance to the insulin. In this research, we have rationally designed and synthesized new succinimide–thiazolidinedione hybrids...

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Bibliographic Details
Main Authors: Mohammed A. Huneif, Mater H. Mahnashi, Muhammad Saeed Jan, Muhammad Shah, Sultan A. Almedhesh, Seham M. Alqahtani, Mohammad Jamaan Alzahrani, Muhammad Ayaz, Farhat Ullah, Umer Rashid, Abdul Sadiq
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
succinimide
thiazolidinedione
antidiabetic
α-glucosidase
α-amylase
PTP1B
Online Access:https://www.mdpi.com/1420-3049/28/3/1207

Internet

https://www.mdpi.com/1420-3049/28/3/1207

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