ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma

ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma

Abstract Background Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. However, the pathways that drive lipid droplet accumulation in ccRCC cel...

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Bibliographic Details
Main Authors: Timothy D. Klasson, Edward L. LaGory, Hongjuan Zhao, Star K. Huynh, Ioanna Papandreou, Eui Jung Moon, Amato J. Giaccia
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cancer & Metabolism
Subjects:
Clear cell renal cell carcinoma (ccRCC)
Lipid droplets
Ferroptosis
Lipid metabolism
Acyl-CoA synthetase 3 (ACSL3)
5-lipoxygenase (5-LOX)
Online Access:https://doi.org/10.1186/s40170-022-00290-z

Internet

https://doi.org/10.1186/s40170-022-00290-z

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