Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors
Brain metastases are a devastating sequela of common primary cancers (e.g., lung, breast, and skin) and have limited effective therapeutic options. Previously, systemic chemotherapy failed to demonstrate significant benefit in patients with brain metastases, but in recent decades, targeted therapies...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2211 |
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| author | Jennifer K. Matsui Haley K. Perlow Rohit K. Raj Ansel P. Nalin Eric J. Lehrer Rupesh Kotecha Daniel M. Trifiletti Shearwood McClelland Kari Kendra Nicole Williams Dwight H. Owen Carolyn J. Presley Evan M. Thomas Sasha J. Beyer Dukagjin M. Blakaj Manmeet S. Ahluwalia Raju R. Raval Joshua D. Palmer |
| author_facet | Jennifer K. Matsui Haley K. Perlow Rohit K. Raj Ansel P. Nalin Eric J. Lehrer Rupesh Kotecha Daniel M. Trifiletti Shearwood McClelland Kari Kendra Nicole Williams Dwight H. Owen Carolyn J. Presley Evan M. Thomas Sasha J. Beyer Dukagjin M. Blakaj Manmeet S. Ahluwalia Raju R. Raval Joshua D. Palmer |
| author_sort | Jennifer K. Matsui |
| collection | DOAJ |
| description | Brain metastases are a devastating sequela of common primary cancers (e.g., lung, breast, and skin) and have limited effective therapeutic options. Previously, systemic chemotherapy failed to demonstrate significant benefit in patients with brain metastases, but in recent decades, targeted therapies and more recently immune checkpoint inhibitors (ICIs) have yielded promising results in preclinical and clinical studies. Furthermore, there is significant interest in harnessing the immunomodulatory effects of radiotherapy (RT) to synergize with ICIs. Herein, we discuss studies evaluating the impact of RT dose and fractionation on the immune response, early studies supporting the synergistic interaction between RT and ICIs, and ongoing clinical trials assessing the benefit of combination therapy in patients with brain metastases. |
| first_indexed | 2024-03-10T00:39:03Z |
| format | Article |
| id | doaj.art-31c7faf82cdd4e0a9e90aedf5f123866 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:39:03Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-31c7faf82cdd4e0a9e90aedf5f1238662023-11-23T15:11:00ZengMDPI AGBiomedicines2227-90592022-09-01109221110.3390/biomedicines10092211Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint InhibitorsJennifer K. Matsui0Haley K. Perlow1Rohit K. Raj2Ansel P. Nalin3Eric J. Lehrer4Rupesh Kotecha5Daniel M. Trifiletti6Shearwood McClelland7Kari Kendra8Nicole Williams9Dwight H. Owen10Carolyn J. Presley11Evan M. Thomas12Sasha J. Beyer13Dukagjin M. Blakaj14Manmeet S. Ahluwalia15Raju R. Raval16Joshua D. Palmer17College of Medicine, The Ohio State University, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USACollege of Medicine, The Ohio State University, Columbus, OH 43210, USADepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USADepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USADepartments of Radiation Oncology and Neurological Surgery, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USADivision of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADivision of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADivision of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADivision of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Medical Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USABrain metastases are a devastating sequela of common primary cancers (e.g., lung, breast, and skin) and have limited effective therapeutic options. Previously, systemic chemotherapy failed to demonstrate significant benefit in patients with brain metastases, but in recent decades, targeted therapies and more recently immune checkpoint inhibitors (ICIs) have yielded promising results in preclinical and clinical studies. Furthermore, there is significant interest in harnessing the immunomodulatory effects of radiotherapy (RT) to synergize with ICIs. Herein, we discuss studies evaluating the impact of RT dose and fractionation on the immune response, early studies supporting the synergistic interaction between RT and ICIs, and ongoing clinical trials assessing the benefit of combination therapy in patients with brain metastases.https://www.mdpi.com/2227-9059/10/9/2211brain metastasesradiotherapyradiation therapysystemic therapyimmune checkpoint inhibitorsimmunoradiotherapy |
| spellingShingle | Jennifer K. Matsui Haley K. Perlow Rohit K. Raj Ansel P. Nalin Eric J. Lehrer Rupesh Kotecha Daniel M. Trifiletti Shearwood McClelland Kari Kendra Nicole Williams Dwight H. Owen Carolyn J. Presley Evan M. Thomas Sasha J. Beyer Dukagjin M. Blakaj Manmeet S. Ahluwalia Raju R. Raval Joshua D. Palmer Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors Biomedicines brain metastases radiotherapy radiation therapy systemic therapy immune checkpoint inhibitors immunoradiotherapy |
| title | Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors |
| title_full | Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors |
| title_fullStr | Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors |
| title_full_unstemmed | Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors |
| title_short | Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors |
| title_sort | treatment of brain metastases the synergy of radiotherapy and immune checkpoint inhibitors |
| topic | brain metastases radiotherapy radiation therapy systemic therapy immune checkpoint inhibitors immunoradiotherapy |
| url | https://www.mdpi.com/2227-9059/10/9/2211 |
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