Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC

Abstract Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and is associated with poor prognosis. The histone H3 lysine 36 methyltransferase SET-domain-containing 2 (SETD2) has been reported to be expressed at low levels and frequently mutated in ccRCC. Ferroptosis,...

Full description

Bibliographic Details
Main Authors: Wei Xue, Wengang Jian, Yuyang Meng, Tengda Wang, Licheng Cai, Yongchun Yu, Yipeng Yu, Zhinan Xia, Cheng Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06057-8