Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer

Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer

The prospect of eradicating malaria continues to be challenging in the face of increasing parasite resistance to antimalarial drugs so that novel antimalarials active against asexual, sexual, and liver-stage malaria parasites are urgently needed. In addition, new antimalarials need to be affordable...

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Bibliographic Details
Main Authors: Yabalu Z. Abacha, Arnold Donkor Forkuo, Stephen Y. Gbedema, Nimisha Mittal, Sabine Ottilie, Frances Rocamora, Elizabeth A. Winzeler, Donelly A. van Schalkwyk, John M. Kelly, Martin C. Taylor, Janette Reader, Lyn-Marie Birkholtz, David R. Lisgarten, Jeremy K. Cockcroft, John N. Lisgarten, Rex A. Palmer, Rosemary C. Talbert, Steven D. Shnyder, Colin W. Wright
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
sustainable pharmaceuticals
halogenation of cryptolepine
Plasmodium falciparum
Plasmodium knowlesi
Trypanosoma brucei
ovarian cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.875647/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.875647/full

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