CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival

CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival

A transplanted organ is always rejected in the absence of any immunosuppressive treatment due to vigorous alloimmunity. However, continuously global immunosuppression with a conventional immunosuppressant may result in severe side effects, including nephrotoxicity, tumors and infections. Tregs have...

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Bibliographic Details
Main Authors: Huazhen Liu, Feifei Qiu, Yuanzhong Wang, Qiaohuang Zeng, Cuihua Liu, Yuchao Chen, Chun-Ling Liang, Qunfang Zhang, Ling Han, Zhenhua Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
regulatory T cell (Treg)
costimulatory blockade
allograft survival
transplantation immunology
PD-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00306/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00306/full

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