Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans

Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans

Abstract Background Genetic diversity is known to confer survival advantage in many species across the tree of life. Here, we hypothesize that such pattern applies to humans as well and could be a result of higher fitness in individuals with higher genomic heterozygosity. Results We use healthy agin...

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Bibliographic Details
Main Authors: Ke Xu, Roman Kosoy, Khader Shameer, Sudhir Kumar, Li Liu, Ben Readhead, Gillian M. Belbin, Hao-Chih Lee, Rong Chen, Joel T. Dudley
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Genetics
Subjects:
Heterozygote advantage
Balancing selection
Fitness
Healthy aging
Human diseases
Electronic health record
Online Access:http://link.springer.com/article/10.1186/s12863-019-0758-4

Internet

http://link.springer.com/article/10.1186/s12863-019-0758-4

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