HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting activation of the transcription factor NF-κB. Global...

Full description

Bibliographic Details
Main Authors: Simon Langer, Christian Hammer, Kristina Hopfensperger, Lukas Klein, Dominik Hotter, Paul D De Jesus, Kristina M Herbert, Lars Pache, Nikaïa Smith, Johannes A van der Merwe, Sumit K Chanda, Jacques Fellay, Frank Kirchhoff, Daniel Sauter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
HIV-1
Vpu
NF-κB
tetherin
immune activation
RNA-Seq
Online Access:https://elifesciences.org/articles/41930

Internet

https://elifesciences.org/articles/41930

Similar Items