Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates

Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates

Deubiquitinases (DUBs) remove ubiquitin from its target proteins. Here, authors compare the regulatory effects of the proteasome and DUBs on the ubiquitinated proteome. They find preferential sets of substrates regulated by DUBs or by the proteasome. Moreover, they find that PARP1 is hyper-ubiquitin...

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Bibliographic Details
Main Authors: Fredrik Trulsson, Vyacheslav Akimov, Mihaela Robu, Nila van Overbeek, David Aureliano Pérez Berrocal, Rashmi G. Shah, Jürgen Cox, Girish M. Shah, Blagoy Blagoev, Alfred C. O. Vertegaal
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30376-7

Internet

https://doi.org/10.1038/s41467-022-30376-7

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