Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates
Deubiquitinases (DUBs) remove ubiquitin from its target proteins. Here, authors compare the regulatory effects of the proteasome and DUBs on the ubiquitinated proteome. They find preferential sets of substrates regulated by DUBs or by the proteasome. Moreover, they find that PARP1 is hyper-ubiquitin...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30376-7 |
| _version_ | 1811250896523231232 |
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| author | Fredrik Trulsson Vyacheslav Akimov Mihaela Robu Nila van Overbeek David Aureliano Pérez Berrocal Rashmi G. Shah Jürgen Cox Girish M. Shah Blagoy Blagoev Alfred C. O. Vertegaal |
| author_facet | Fredrik Trulsson Vyacheslav Akimov Mihaela Robu Nila van Overbeek David Aureliano Pérez Berrocal Rashmi G. Shah Jürgen Cox Girish M. Shah Blagoy Blagoev Alfred C. O. Vertegaal |
| author_sort | Fredrik Trulsson |
| collection | DOAJ |
| description | Deubiquitinases (DUBs) remove ubiquitin from its target proteins. Here, authors compare the regulatory effects of the proteasome and DUBs on the ubiquitinated proteome. They find preferential sets of substrates regulated by DUBs or by the proteasome. Moreover, they find that PARP1 is hyper-ubiquitinated in response to DUB inhibition, which increases its enzymatic activity. |
| first_indexed | 2024-04-12T16:11:36Z |
| format | Article |
| id | doaj.art-31d21d51d10f47c7b838fbd4612da909 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T16:11:36Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-31d21d51d10f47c7b838fbd4612da9092022-12-22T03:25:52ZengNature PortfolioNature Communications2041-17232022-05-0113111710.1038/s41467-022-30376-7Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substratesFredrik Trulsson0Vyacheslav Akimov1Mihaela Robu2Nila van Overbeek3David Aureliano Pérez Berrocal4Rashmi G. Shah5Jürgen Cox6Girish M. Shah7Blagoy Blagoev8Alfred C. O. Vertegaal9Cell and Chemical Biology, Leiden University Medical CentreDepartment of Biochemistry and Molecular Biology, University of Southern DenmarkLaboratory for Skin Cancer Research, CHU de Québec Laval University Hospital Research CentreCell and Chemical Biology, Leiden University Medical CentreCell and Chemical Biology, Leiden University Medical CentreLaboratory for Skin Cancer Research, CHU de Québec Laval University Hospital Research CentreComputational Systems Biochemistry Research Group, Max-Planck Institute of BiochemistryLaboratory for Skin Cancer Research, CHU de Québec Laval University Hospital Research CentreDepartment of Biochemistry and Molecular Biology, University of Southern DenmarkCell and Chemical Biology, Leiden University Medical CentreDeubiquitinases (DUBs) remove ubiquitin from its target proteins. Here, authors compare the regulatory effects of the proteasome and DUBs on the ubiquitinated proteome. They find preferential sets of substrates regulated by DUBs or by the proteasome. Moreover, they find that PARP1 is hyper-ubiquitinated in response to DUB inhibition, which increases its enzymatic activity.https://doi.org/10.1038/s41467-022-30376-7 |
| spellingShingle | Fredrik Trulsson Vyacheslav Akimov Mihaela Robu Nila van Overbeek David Aureliano Pérez Berrocal Rashmi G. Shah Jürgen Cox Girish M. Shah Blagoy Blagoev Alfred C. O. Vertegaal Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates Nature Communications |
| title | Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates |
| title_full | Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates |
| title_fullStr | Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates |
| title_full_unstemmed | Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates |
| title_short | Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates |
| title_sort | deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates |
| url | https://doi.org/10.1038/s41467-022-30376-7 |
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