HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells

HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells

BackgroundDespite the significant progress achieved in understanding the pathology and clinical management of SARS-CoV-2 infection, still pathogenic and clinical issues need to be clarified. Treatment with modulators of epigenetic targets, i.e., epidrugs, is a current therapeutic option in several c...

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Bibliographic Details
Main Authors: Flavia Trionfetti, Tonino Alonzi, Giulio Bontempi, Michela Terri, Cecilia Battistelli, Claudia Montaldo, Federica Repele, Dante Rotili, Sergio Valente, Clemens Zwergel, Giulia Matusali, Fabrizio Maggi, Delia Goletti, Marco Tripodi, Antonello Mai, Raffaele Strippoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
HDAC (histone deacetylase)
SARS-CoV-2
ACE2 regulation
TMPRSS2 expression
mesothelial cells
pleura
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1257683/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1257683/full

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