Vascular stiffening in aging females with a hypertension‐induced HIF2A gain‐of‐function mutation

Vascular stiffening in aging females with a hypertension‐induced HIF2A gain‐of‐function mutation

Abstract Pulmonary arterial hypertension (PAH) is more prevalent in females than males; the causes of this sex difference have not been adequately explored. Gain‐of‐function (GOF) mutations in hypoxia‐inducible factor 2α (HIF2A) lead to PAH and thrombotic consequences in patients and mice. Additiona...

Full description

Bibliographic Details
Main Authors: Eugenia Volkova, Linda Procell, Lingyang Kong, Lakshmi Santhanam, Sharon Gerecht
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Bioengineering & Translational Medicine
Subjects:
Arterial Stiffening
Extracellular Matrix
HIF
HIF2a
Hypertension
Hypoxia
Online Access:https://doi.org/10.1002/btm2.10403

Internet

https://doi.org/10.1002/btm2.10403

Similar Items