Erythronate utilization activates VdtR regulating its metabolism to promote Brucella proliferation, inducing abortion in mice

Erythronate utilization activates VdtR regulating its metabolism to promote Brucella proliferation, inducing abortion in mice

ABSTRACT Brucella is a facultative intracellular pathogen that preferentially colonizes reproductive organs and utilizes erythritol as a preferred carbon source for its survival and proliferation. In this study, we identified a virulence-related DeoR-family transcriptional regulator (VdtR) and an er...

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Bibliographic Details
Main Authors: Yi Yin, Tian Fang, Zhengmin Lian, Dong Zuo, Hai Hu, Guangdong Zhang, Chan Ding, Mingxing Tian, Shengqing Yu
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
Brucella
VdtR regulation
erythronate metabolic pathway
abortion
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02074-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02074-23

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