Interferon-γ Produced by EBV-Positive Neoplastic NK-Cells Induces Differentiation into Macrophages and Procoagulant Activity of Monocytes, Which Leads to HLH

Interferon-γ Produced by EBV-Positive Neoplastic NK-Cells Induces Differentiation into Macrophages and Procoagulant Activity of Monocytes, Which Leads to HLH

Epstein–Barr virus (EBV)-positive T- or NK-cell neoplasms show progressive systemic inflammation and abnormal blood coagulation causing hemophagocytic lymphohistiocytosis (HLH). It was reported that inflammatory cytokines were produced and secreted by EBV-positive neoplastic T- or NK-cells. These cy...

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Bibliographic Details
Main Authors: Mayumi Yoshimori, Miwako Nishio, Ayaka Ohashi, Megumi Tateishi, Ayaka Mimura, Naomi Wada, Minori Saito, Norio Shimizu, Ken-Ichi Imadome, Ayako Arai
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
EBV-positive T- or NK-cell neoplasms
hemophagocytic lymphohistiocytosis
disseminated intravascular coagulation
interferon-γ
macrophage
differentiation
Online Access:https://www.mdpi.com/2072-6694/13/20/5097

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https://www.mdpi.com/2072-6694/13/20/5097

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