Urinary Mitochondrial DNA Induces an Inflammatory Response in Peripheral Blood Mononuclear Cells

Urinary Mitochondrial DNA Induces an Inflammatory Response in Peripheral Blood Mononuclear Cells

Background: Mitochondria are semiautonomous cell organelles having its own nucleic acid. Mitochondrial DNA (Mt-DNA) remain in hypomethylated (CpG) state and impose an immunogenic response by binding to the toll-like receptor (TLR-9) through the NF-kB pathway. Innate immune cells recognize the hypome...

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Váldodahkkit: Brijesh Yadav, Narayan Prasad, Ravi Shanker Kushwaha, Ankita Singh, Deependra Yadav, Dharmendra Singh Bhadauria, Anupma Kaul
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Wolters Kluwer Medknow Publications 2024-06-01
Ráidu:Indian Journal of Transplantation
Fáttát:
cpg oligodeoxynucleotide
peripheral blood mononuclear cells
toll-like receptor-9
urinary mitochondrial dna
Liŋkkat:https://journals.lww.com/10.4103/ijot.ijot_94_23

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https://journals.lww.com/10.4103/ijot.ijot_94_23

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