Feline XRCC4 undergoes rapid Ku‐dependent recruitment to DNA damage sites

Radiation and chemotherapy resistance remain some of the greatest challenges in human and veterinary cancer therapies. XRCC4, an essential molecule for nonhomologous end joining repair, is a promising target for radiosensitizers. Genetic variants and mutations of XRCC4 contribute to cancer susceptib...

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Bibliographic Details
Main Authors: Manabu Koike, Yasutomo Yutoku, Aki Koike
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:FEBS Open Bio
Subjects:
Online Access:https://doi.org/10.1002/2211-5463.13363