Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

Abstract Background Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlying mechanism is still unknown. Since exosomes-derived epidermal growth...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Stefania Raimondo, Laura Saieva, Emanuela Vicario, Marzia Pucci, Denise Toscani, Mauro Manno, Samuele Raccosta, Nicola Giuliani, Riccardo Alessandro
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: BMC 2019-01-01
Sarja:Journal of Hematology & Oncology
Aiheet:
Exosomes
Multiple myeloma
Bone disease
Epidermal growth factor receptor
Amphiregulin
Interleukin 8
Linkit:http://link.springer.com/article/10.1186/s13045-018-0689-y

Internet

http://link.springer.com/article/10.1186/s13045-018-0689-y

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