Intermediate filaments ensure resiliency of single carcinoma cells, while active contractility of the actin cortex determines their invasive potential

Intermediate filaments ensure resiliency of single carcinoma cells, while active contractility of the actin cortex determines their invasive potential

During the epithelial-to-mesenchymal transition, the intracellular cytoskeleton undergoes severe reorganization which allows epithelial cells to transition into a motile mesenchymal phenotype. Among the different cytoskeletal elements, the intermediate filaments keratin (in epithelial cells) and vim...

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Bibliographic Details
Main Authors: Carlotta Ficorella, Hannah Marie Eichholz, Federico Sala, Rebeca Martínez Vázquez, Roberto Osellame, Josef A Käs
Format: Article
Language:English
Published: IOP Publishing 2021-01-01
Series:New Journal of Physics
Subjects:
metastatic invasion
cancer cell migration in confinement
intermediate filament cytoskeleton
cortical contractility
Online Access:https://doi.org/10.1088/1367-2630/ac1899

Internet

https://doi.org/10.1088/1367-2630/ac1899

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