Attenuated WNV-poly(A) exerts a broad-spectrum oncolytic effect by selective virus replication and CD8+ T cell-dependent immune response

Attenuated WNV-poly(A) exerts a broad-spectrum oncolytic effect by selective virus replication and CD8+ T cell-dependent immune response

As an emerging tumor therapy, ideal oncolytic viruses preferentially replicate in malignant cells, reverse the immunosuppressive tumor microenvironment, and eventually can be eliminated by the patient. It is of great significance for cancer treatment to discover new excellent oncolytic viruses. Here...

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Bibliographic Details
Main Authors: Jing Liu, Yan-Yan Hu, Qiu-Yan Zhang, Ya-Nan Zhang, Na Li, Zhe-Rui Zhang, Shun-Li Zhan, Lei Gao, Cheng-Lin Deng, Xiao-Dan Li, Shao-Peng Yuan, Yuan-Qiao He, Han-Qing Ye, Bo Zhang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
WNV-poly(A)
Oncolytic virus
IFN-I-dependent selectivity
CD8+ T cell
Immunity therapy
Broad spectrum
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222014834

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http://www.sciencedirect.com/science/article/pii/S0753332222014834

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