Efficient Synthesis of 1<i>H</i>-Benzo[4,5]imidazo[1,2-<i>c</i>][1,3]oxazin-1-one Derivatives Using Ag<sub>2</sub>CO<sub>3</sub>/TFA-Catalyzed 6-<i>endo-dig</i> Cyclization: Reaction Scope and Mechanistic Study

Efficient Synthesis of 1<i>H</i>-Benzo[4,5]imidazo[1,2-<i>c</i>][1,3]oxazin-1-one Derivatives Using Ag<sub>2</sub>CO<sub>3</sub>/TFA-Catalyzed 6-<i>endo-dig</i> Cyclization: Reaction Scope and Mechanistic Study

A small library of 1<i>H</i>-benzo[4,5]imidazo[1,2-<i>c</i>][1,3]oxazin-1-one derivatives was prepared in good to excellent yields, involving a Ag<sub>2</sub>CO<sub>3</sub>/TFA-catalyzed intramolecular oxacyclization of <i>N-Boc</i>-2-alkyn...

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Bibliographic Details
Main Authors: Abdelkarim El Qami, Badr Jismy, Mohamed Akssira, Johan Jacquemin, Abdellatif Tikad, Mohamed Abarbri
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
6-<i>endo-dig</i> cyclization
silver
oxacyclization
catalytic process
1H-benzo[4,5]imidazo[1,2-<i>c</i>][1,3]oxazin-1-ones
computational study
Online Access:https://www.mdpi.com/1420-3049/28/5/2403

Internet

https://www.mdpi.com/1420-3049/28/5/2403

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